{"id":7926,"date":"2026-07-17T10:56:22","date_gmt":"2026-07-17T07:56:22","guid":{"rendered":"https:\/\/www.schooler.org.ua\/uk-uanova-tabletka-dlja-znizhennja-holesterinu-vid-merck-vijshla-u\/"},"modified":"2026-07-17T10:56:22","modified_gmt":"2026-07-17T07:56:22","slug":"uk-uanova-tabletka-dlja-znizhennja-holesterinu-vid-merck-vijshla-u","status":"publish","type":"post","link":"https:\/\/www.schooler.org.ua\/cs\/uk-uanova-tabletka-dlja-znizhennja-holesterinu-vid-merck-vijshla-u\/","title":{"rendered":"Nov\u00e1 pilulka na sn\u00ed\u017een\u00ed cholesterolu od spole\u010dnosti Merck jde do prodeje"},"content":{"rendered":"

Americk\u00fd \u00fa\u0159ad pro potraviny a l\u00e9\u010diva (FDA) pr\u00e1v\u011b schv\u00e1lil enalixitid<\/strong>. Jedn\u00e1 se o pilulku, kter\u00e1 je \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e statiny. <\/p>\n

V\u0161ichni jsme sly\u0161eli varov\u00e1n\u00ed o \u201e\u0161patn\u00e9m\u201c cholesterolu (LDL<\/strong> ). Tento lipoprotein s n\u00edzkou hustotou se ukl\u00e1d\u00e1 na st\u011bn\u00e1ch tepen, vytv\u00e1\u0159\u00ed plak a zvy\u0161uje riziko srde\u010dn\u00edch onemocn\u011bn\u00ed nebo mrtvice. Po cel\u00e1 desetilet\u00ed byly zlat\u00fdm standardem l\u00e9\u010dby statiny, kter\u00e9 pom\u00e1haj\u00ed udr\u017eet hladinu cholesterolu pod 100 mg\/dl. Nov\u00fd l\u00e9k? Sni\u017euje ji na 50 mg\/dl a je\u0161t\u011b ni\u017e\u0161\u00ed. Toto jsou \u00fadaje z klinick\u00fdch studi\u00ed. <\/p>\n

Obchodn\u00ed n\u00e1zev l\u00e9ku je Lipfendra. Maloobchodn\u00ed cena je 315 $ za 30denn\u00ed kurz. Zn\u00ed to draho? Ale zva\u017ete inhibitory PCSK9, kter\u00e9 jsou injek\u010dn\u00ed a jsou dostupn\u00e9 ji\u017e deset let. D\u011blaj\u00ed to sam\u00e9, ale stoj\u00ed mnohem v\u00edc. <\/p>\n

Eric Topol z Scripps Translatology Research Institute to \u0159\u00edk\u00e1 bez obalu:<\/p>\n

\n

“Je hezk\u00e9 m\u00edt pilulku schv\u00e1lenou FDA.” <\/p>\n<\/blockquote>\n

Poznamen\u00e1v\u00e1, \u017ee l\u00e9k p\u016fsob\u00ed prost\u0159ednictv\u00edm zn\u00e1m\u00e9ho biologick\u00e9ho c\u00edle a poskytuje sn\u00ed\u017een\u00ed LDL srovnateln\u00e9 s drah\u00fdmi injekcemi. Pro\u010d platit v\u00edce za injekci, kdy\u017e m\u016f\u017eete spolknout pilulku? <\/p>\n

L\u00e9k byl vyvinut spole\u010dnost\u00ed Merck, stejnou spole\u010dnost\u00ed, kter\u00e1 vydala lovastatin ji\u017e v roce 1987. Historie se opakuje. Enalixitid se zam\u011b\u0159uje na PCSK9<\/strong>, protein produkovan\u00fd j\u00e1try, kter\u00fd norm\u00e1ln\u011b zpomaluje odstra\u0148ov\u00e1n\u00ed cholesterolu z t\u011bla. Blokujte tento protein a cholesterol zmiz\u00ed. Vedlej\u0161\u00ed \u00fa\u010dinky? Asi stejn\u011b jako placebo. Po \u0161esti m\u011bs\u00edc\u00edch klinick\u00e9 studie prok\u00e1zaly 60% sn\u00ed\u017een\u00ed hladiny cholesterolu u dosp\u011bl\u00fdch s rizikem rozvoje aterosklerotick\u00e9ho kardiovaskul\u00e1rn\u00edho onemocn\u011bn\u00ed<\/strong>. <\/p>\n

Klinick\u00e1 doporu\u010den\u00ed se zm\u011bnila v b\u0159eznu tohoto roku. American Heart Association a American College of Cardiology uvedly, \u017ee pokud v\u00e1m hroz\u00ed srde\u010dn\u00ed infarkt, c\u00edlov\u00e1 hladina LDL by m\u011bla b\u00fdt pod 70 mg\/dl. P\u0159i vysok\u00e9m riziku \u2013 pod 55 mg\/dl. Enalixitide tuto mezeru dokonale vypl\u0148uje. Podle norem se nav\u00edc st\u00e1le doporu\u010duje nechat si ka\u017ed\u00fdch p\u011bt let zkontrolovat hladinu cholesterolu. <\/p>\n

Existuje ji\u017e dostatek d\u016fkaz\u016f o nebezpe\u010d\u00ed vysok\u00fdch hladin LDL. Ale zabra\u0148uje tento konkr\u00e9tn\u00ed l\u00e9k infarktu? Spole\u010dnost Merck v sou\u010dasn\u00e9 dob\u011b prov\u00e1d\u00ed p\u0159\u00edslu\u0161n\u00e9 testy. Budeme si muset po\u010dkat a uvid\u00edme, zda ni\u017e\u0161\u00ed \u010d\u00edsla znamenaj\u00ed z\u00e1chranu skute\u010dn\u00fdch \u017eivot\u016f, nebo jde jen o dal\u0161\u00ed drah\u00fd kousek l\u00e9\u010debn\u00e9ho syst\u00e9mu. <\/p>\n

Od\u016fvod\u0148uje cena \u00fa\u010dinnost? Na tuto ot\u00e1zku m\u016f\u017ee p\u0159esn\u011b odpov\u011bd\u011bt pouze v\u00e1\u0161 l\u00e9ka\u0159.<\/p>\n","protected":false},"excerpt":{"rendered":"

Americk\u00fd \u00fa\u0159ad pro potraviny a l\u00e9\u010diva (FDA) pr\u00e1v\u011b schv\u00e1lil enalixitid. Jedn\u00e1 se o pilulku, kter\u00e1 je \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e statiny. V\u0161ichni jsme sly\u0161eli varov\u00e1n\u00ed o \u201e\u0161patn\u00e9m\u201c cholesterolu (LDL ). Tento lipoprotein s n\u00edzkou hustotou se ukl\u00e1d\u00e1 na st\u011bn\u00e1ch tepen, vytv\u00e1\u0159\u00ed plak a zvy\u0161uje riziko srde\u010dn\u00edch onemocn\u011bn\u00ed nebo mrtvice. Po cel\u00e1 desetilet\u00ed byly zlat\u00fdm standardem l\u00e9\u010dby statiny, […]<\/p>\n","protected":false},"author":1,"featured_media":7925,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":""},"categories":[1],"tags":[],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/posts\/7926"}],"collection":[{"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/comments?post=7926"}],"version-history":[{"count":0,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/posts\/7926\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/media\/7925"}],"wp:attachment":[{"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/media?parent=7926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/categories?post=7926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/tags?post=7926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}