Pokud se v\u00e1m v hrudi skr\u00fdv\u00e1 su\u0161en\u00e1 meru\u0148ka, pak je to velikost brzl\u00edku. Tento org\u00e1n, skryt\u00fd mezi pl\u00edcemi, v\u011bt\u0161ina lid\u00ed prost\u011b ignoruje. Ten na opl\u00e1tku tak\u00e9 p\u0159edst\u00edr\u00e1, \u017ee neexistuje. <\/p>\n
Po cel\u00e1 desetilet\u00ed v\u011bdci sledovali tuto drobnou \u017el\u00e1zu \u840e\u7f29 (zmen\u0161ov\u00e1n\u00ed). Po pubert\u011b za\u010d\u00edn\u00e1 brzl\u00edk atrofovat a konsensus byl jednoduch\u00fd: jeho pr\u00e1ce je hotov\u00e1. Jeho hlavn\u00edm \u00fakolem \u2013 produkovat T-bu\u0148ky bojuj\u00edc\u00ed proti patogen\u016fm \u2013 bylo z velk\u00e9 \u010d\u00e1sti d\u011btstv\u00ed. Po tomto obdob\u00ed z\u016fst\u00e1v\u00e1 v imunitn\u00edm syst\u00e9mu pouze zbytkov\u00fdm zbytkem. <\/p>\n
M\u00fdlili se. <\/p>\n
Nov\u00e1 studie publikovan\u00e1 v Nature Communications<\/em> nazna\u010duje, \u017ee brzl\u00edk udr\u017euje v \u0161achu n\u011bco mnohem matouc\u00edho: z\u00e1n\u011bt souvisej\u00edc\u00ed s v\u011bkem<\/strong>. D\u011bl\u00e1 to pomoc\u00ed hormonu zvan\u00e9ho thymulin. <\/p>\n Fumito Ito, hlavn\u00ed autor studie a imunolog z Keck College of Medicine na University of Southern California (USC), naz\u00fdv\u00e1 roli hormonu v procesu st\u00e1rnut\u00ed \u201epon\u011bkud p\u0159ehl\u00ed\u017eenou\u201c. Asi 50 let z\u016fstal thymulin na periferii v\u011bdeck\u00fdch z\u00e1jm\u016f. <\/p>\n Nyn\u00ed se dostal do p\u0159edn\u00ed linie. <\/p>\n U star\u00fdch my\u0161\u00ed thymulin potla\u010duje syst\u00e9mov\u00fd z\u00e1n\u011bt, kter\u00fd n\u00e1s s v\u011bkem stahuje dol\u016f. Tento stav, zn\u00e1m\u00fd jako \u201einflammaging\u201c (z anglick\u00e9ho inflammation<\/em> a aging<\/em> ), je hnac\u00edm motorem chronick\u00fdch onemocn\u011bn\u00ed. To je d\u016fvod, pro\u010d v\u00e1s bol\u00ed kolena, zvy\u0161uje se mozkov\u00e1 mlha a v\u00e1\u0161 imunitn\u00ed syst\u00e9m za\u010d\u00edn\u00e1 \u00fato\u010dit na va\u0161e t\u011blo. <\/p>\n Studie zjistila, \u017ee my\u0161i s vy\u0161\u0161\u00edmi hladinami thymulinu m\u011bly m\u00e9n\u011b z\u00e1n\u011btliv\u00fdch cytokin\u016f. Cytokiny jsou samoz\u0159ejm\u011b proteiny ur\u010den\u00e9 k boji s infekcemi. Ale kdy je jich p\u0159\u00edli\u0161? Je to jako ohe\u0148 ve va\u0161ich \u017eil\u00e1ch. Myeloidn\u00ed bu\u0148ky u t\u011bchto my\u0161\u00ed produkovaly m\u00e9n\u011b cytokin\u016f. Z\u00e1n\u011bt ustoupil. <\/p>\n Nejde jen o to, c\u00edtit se l\u00e9pe v 70 letech. Tady jde o schopnost tolerovat agresivn\u011bj\u0161\u00ed l\u00e9\u010dbu. <\/p>\n V\u011bdci se pod\u00edvali nejen na zdrav\u00e9 my\u0161i, ale tak\u00e9 na star\u00e9 my\u0161i s rakovinou. P\u00edchli thymulin. V\u00fdsledky byly dramatick\u00e9. R\u016fst n\u00e1doru se zpomalil. M\u00edra p\u0159e\u017eit\u00ed se zlep\u0161ila. A my\u0161i l\u00e9pe reagovaly na standardn\u00ed l\u00e9\u010dbu. <\/p>\n P\u0159edchoz\u00ed d\u016fkazy ji\u017e nazna\u010dovaly souvislost mezi zdrav\u00edm brzl\u00edku a dlouhov\u011bkost\u00ed. Anal\u00fdza ~27 000 l\u00e9ka\u0159sk\u00fdch z\u00e1znam\u016f zve\u0159ejn\u011bn\u00fdch v b\u0159eznu zjistila, \u017ee aktivn\u00ed funkce brzl\u00edku koreluje s ni\u017e\u0161\u00edm v\u00fdskytem rakoviny plic, kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed a del\u0161\u00ed o\u010dek\u00e1vanou d\u00e9lkou \u017eivota. Ale korelace nen\u00ed kauzalita. Nelze \u0159\u00edci, \u017ee brzl\u00edk zp\u016fsobuje<\/em> dlouhov\u011bkost jen proto, \u017ee dlouhov\u011bc\u00ed lid\u00e9 maj\u00ed \u010dasto zdrav\u00fd brzl\u00edk. <\/p>\n Tato studie p\u0159esn\u011b stanov\u00ed vztah p\u0159\u00ed\u010diny a n\u00e1sledku. <\/p>\n “Na\u0161e studie ukazuje, \u017ee tento hormon m\u016f\u017ee postupn\u011b zpomalit r\u016fst n\u00e1doru, zlep\u0161it p\u0159e\u017eit\u00ed a tak\u00e9 zlep\u0161it \u00fa\u010dinnost imunoterapie rakoviny.” Potenci\u00e1l protin\u00e1dorov\u00e9 terapie<\/strong> je obrovsk\u00fd. Proto\u017ee je tento hormon t\u011blu p\u0159irozen\u00fd, Ito o\u010dek\u00e1v\u00e1 minim\u00e1ln\u00ed vedlej\u0161\u00ed \u00fa\u010dinky. To je odv\u00e1\u017en\u00e9 tvrzen\u00ed v poli pln\u00e9m toxick\u00fdch l\u00e9\u010debn\u00fdch postup\u016f. Imunoterapie je \u00fa\u010dinn\u00e1, ale drah\u00e1 a pro n\u011bkter\u00e9 pacienty \u010dasto ne\u00fa\u010dinn\u00e1. P\u0159id\u00e1n\u00ed levn\u00e9ho p\u0159\u00edrodn\u00edho regul\u00e1toru do mixu m\u016f\u017ee zm\u011bnit hru. <\/p>\n Nejprve to mus\u00edme potvrdit experimenty na lidech. <\/p>\n Modely my\u0161\u00ed jsou u\u017eite\u010dn\u00e9, ale nejsme to my. Jejich \u017eivotnost je krat\u0161\u00ed. Jejich imunitn\u00ed syst\u00e9m je navr\u017een jinak. Biologick\u00e9 procesy jsou v\u0161ak tak bl\u00edzko, \u017ee to d\u00e1v\u00e1 d\u016fvod k nad\u011bji. <\/p>\n Studie nazna\u010duje, \u017ee brzl\u00edk nen\u00ed poz\u016fstatkem minulosti. Je aktivn\u00edm \u00fa\u010dastn\u00edkem na\u0161eho procesu st\u00e1rnut\u00ed. Pokud m\u016f\u017eeme pou\u017e\u00edt thymulin, m\u016f\u017eeme b\u00fdt schopni zm\u00edrnit nejhor\u0161\u00ed \u00fa\u010dinky z\u00e1n\u011btu<\/strong>. <\/p>\n P\u0159em\u00fd\u0161lejte o tom chv\u00edli. Hormon, kter\u00fd nejen l\u00e9\u010d\u00ed rakovinu, ale tak\u00e9 uklid\u0148uje z\u00e1n\u011btliv\u00fd \u201ehluk\u201c, kter\u00fd v pr\u016fb\u011bhu \u010dasu zp\u016fsobuje zmatek v na\u0161em t\u011ble. <\/p>\n Brzl\u00edk se ur\u010dit\u011b zmen\u0161uje. Jeho vliv ale nemus\u00ed zmizet.<\/p>\n","protected":false},"excerpt":{"rendered":" Pokud se v\u00e1m v hrudi skr\u00fdv\u00e1 su\u0161en\u00e1 meru\u0148ka, pak je to velikost brzl\u00edku. Tento org\u00e1n, skryt\u00fd mezi pl\u00edcemi, v\u011bt\u0161ina lid\u00ed prost\u011b ignoruje. Ten na opl\u00e1tku tak\u00e9 p\u0159edst\u00edr\u00e1, \u017ee neexistuje. Po cel\u00e1 desetilet\u00ed v\u011bdci sledovali tuto drobnou \u017el\u00e1zu \u840e\u7f29 (zmen\u0161ov\u00e1n\u00ed). Po pubert\u011b za\u010d\u00edn\u00e1 brzl\u00edk atrofovat a konsensus byl jednoduch\u00fd: jeho pr\u00e1ce je hotov\u00e1. Jeho hlavn\u00edm \u00fakolem […]<\/p>\n","protected":false},"author":1,"featured_media":7943,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":""},"categories":[1],"tags":[],"wpm_language_slugs":{"cs":"brzlik-a-thymulin-jak-zmensujici-se-organ-bojuje-se-zanetem","de":"thymus-und-thymulin-wie-ein-schrumpfendes-organ-altersbedingte","en":"the-thymus-and-thymulin-how-a-shrinking-organ-fights-age-related","es":"el-timo-y-la-timulina-como-un-organo-cada-vez-mas-reducido-combate","fr":"le-thymus-et-la-thymuline-comment-un-organe-en-retrecissement-combat","id":"timus-dan-timulin-bagaimana-organ-yang-menyusut-melawan-peradangan","it":"il-timo-e-la-timulina-come-un-organo-in-contrazione-combatte","nl":"de-thymus-en-thymuline-hoe-een-kleiner-wordend-orgaan","pl":"grasica-i-tymulina-jak-kurczacy-sie-narzad-zwalcza-zapalenie","pt":"o-timo-e-a-timulina-como-um-orgao-encolhido-combate-a-inflamacao","ru-ru":"timus-i-timulin-kak-umenshajuschijsja-organ-boretsja-s-vozrastnym","uk-ua":"timus-i-timulin-jak-organ-scho-zmenshuyetsja-boretsja-z-vikovim"},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/posts\/7944"}],"collection":[{"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/comments?post=7944"}],"version-history":[{"count":0,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/posts\/7944\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/media\/7943"}],"wp:attachment":[{"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/media?parent=7944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/categories?post=7944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.schooler.org.ua\/cs\/wp-json\/wp\/v2\/tags?post=7944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Role thymulinu p\u0159i sni\u017eov\u00e1n\u00ed z\u00e1n\u011btu<\/h2>\n
Pro\u010d je to d\u016fle\u017eit\u00e9 pro dlouhov\u011bkost a l\u00e9\u010dbu rakoviny<\/h2>\n
\n
\n– Fumito Ito<\/p>\n<\/blockquote>\nKdy lid\u00e9 uvid\u00ed tyto v\u00fdhody?<\/h2>\n